A 4250

Drug Profile

A 4250

Alternative Names: A4250

Latest Information Update: 21 Mar 2018

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At a glance

  • Originator Albireo AB
  • Developer Albireo AB; Albireo Pharma
  • Class Antipruritics
  • Mechanism of Action Sodium-bile acid cotransporter-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary biliary cirrhosis; Intrahepatic cholestasis; Alagille syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Intrahepatic cholestasis
  • Phase II Primary biliary cirrhosis; Pruritus
  • Phase I Alagille syndrome
  • Preclinical Non-alcoholic steatohepatitis

Most Recent Events

  • 01 Mar 2018 National Institute of Diabetes and Digestive and Kidney Diseases withdraws the BRAVO-1 phase III trial in Nonalcoholic fatty liver disease and Nonalcoholic steatohepatitis, prior to enrolment, because funding not available (NCT03451279)
  • 30 Jan 2018 Phase-III clinical trials in Intrahepatic cholestasis (PO) (Albireo Pharma pipeline, January 2018)
  • 20 Oct 2017 Pharmacokinetics, efficacy and adverse events data from a phase II trial in Primary biliary cirrhosis and Cholestatic pruritus presented at the 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2017)
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