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Selinexor- Karyopharm Therapeutics

Drug Profile

Selinexor- Karyopharm Therapeutics

Alternative Names: ATG-010; CRM1-nuclear-export-inhibitor; KPT-330; NEXPOVIO; ONO 7705; Selinisso; TP-53; XPOVIO

Latest Information Update: 22 Mar 2024

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At a glance

  • Originator Karyopharm Therapeutics
  • Developer Antengene Corporation; Cardiff University; Grupo Espanol de Investigacion en Sarcomas; Karyopharm Therapeutics; Menarini; Ono Pharmaceutical; Promedico; University of Texas Southwestern Medical Center
  • Class Acrylamides; Anti-infectives; Antineoplastics; Antivirals; Fluorinated hydrocarbons; Foot disorder therapies; Hydrazines; Pyrazines; Small molecules; Triazoles
  • Mechanism of Action Exportin-1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Multiple myeloma; Myelofibrosis; Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Diffuse large B cell lymphoma; Multiple myeloma
  • Phase III Endometrial cancer; Liposarcoma; Myelofibrosis
  • Phase II/III Acute myeloid leukaemia; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase II Colorectal cancer; COVID 2019 infections; Malignant melanoma; Ovarian cancer; Peripheral T-cell lymphoma; Thymic epithelial tumour; Thymoma; Triple negative breast cancer
  • Phase I/II Gastrointestinal stromal tumours; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Solid tumours
  • Phase I Liver cancer
  • Preclinical Sepsis
  • No development reported B-cell lymphoma; Cervical cancer; Chronic lymphocytic leukaemia; Extranodal NK-T-cell lymphoma; Glioma; HER2 positive breast cancer; Neuroendocrine tumours; Osteosarcoma; Soft tissue sarcoma
  • Discontinued Cutaneous T-cell lymphoma; Diabetic foot ulcer; Gastric cancer; Glioblastoma; Oesophageal cancer; Prostate cancer; Rectal cancer; Richter's syndrome; Small cell lung cancer; Squamous cell cancer

Most Recent Events

  • 22 Mar 2024 Karyopharm Therapeutics plans a phase II trial in Myelofibrosis and Thrombocytopenia (Monotherapy, Treatment naïve) (PO, tablet) in March 2024 (NCT05980806)
  • 28 Feb 2024 No recent reports of development identified for phase-I development in Osteosarcoma(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Spain (PO, Tablet)
  • 28 Feb 2024 No recent reports of development identified for phase-I development in Soft tissue sarcoma(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Spain (PO, Tablet)
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