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Research programme: G-protein-coupled bile acid receptor-1 agonists - Ardelyx

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Drug Profile

Research programme: G-protein-coupled bile acid receptor-1 agonists - Ardelyx

Alternative Names: Gpbar1 Agonists - Ardelyx; RDX 009; RDX 98940; RDX009-01; TGR5 Agonists - Ardelyx

Latest Information Update: 08 May 2023

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At a glance

  • Originator Ardelyx
  • Class Anti-inflammatories; Antidiarrhoeals; Small molecules
  • Mechanism of Action GPBAR1 protein agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Diarrhoea; Inflammatory bowel diseases; Non-alcoholic steatohepatitis; Short bowel syndrome; Type 2 diabetes mellitus

Most Recent Events

  • 30 Apr 2023 METiS Therapeutics in-licenses TGR5 agonist compounds from Ardelyx
  • 21 Mar 2023 Discontinued - Preclinical for Diarrhoea in USA (PO)
  • 21 Mar 2023 Discontinued - Preclinical for Inflammatory bowel diseases in USA (PO)

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