Research programme: G-protein-coupled bile acid receptor-1 agonists - Ardelyx

Drug Profile

Research programme: G-protein-coupled bile acid receptor-1 agonists - Ardelyx

Alternative Names: Gpbar1 Agonists - Ardelyx; RDX 009; RDX 98940; RDX009-01; TGR5 Agonists - Ardelyx

Latest Information Update: 13 Jul 2017

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At a glance

  • Originator Ardelyx
  • Class Small molecules
  • Mechanism of Action GPBAR1 protein agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Diarrhoea; Inflammatory bowel diseases; Non-alcoholic steatohepatitis; Short bowel syndrome
  • Discontinued Type 2 diabetes mellitus

Most Recent Events

  • 06 May 2017 Pharmacokinetics data from a preclinical study in Non-alcoholic steatohepatitis presented at the Digestive Disease Week 2017 (DDW - 2017)
  • 09 May 2016 Ardelyx plans to file an IND application for RDX 98940 to the US FDA
  • 10 Sep 2015 Ardelyx plans to file an IND application for RDX 009 with the US FDA
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