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Venglustat - Sanofi

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Drug Profile

Venglustat - Sanofi

Alternative Names: Genz-682452-AA; Genz-682452-AU; GZ-402671; GZ/SAR402671; GZ/SAR402671A; Ibiglustat; SAR-402671; SAR402671A; Venglustat malate; Venglustat malate - Sanofi

Latest Information Update: 19 Feb 2024

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At a glance

  • Originator Genzyme Corporation
  • Developer Sanofi; Sanofi Genzyme
  • Class Antiparkinsonians; Azabicyclo compounds; Carbamates; Small molecules; Thiazoles; Urologics
  • Mechanism of Action Glucosylceramide synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycystic kidney disease
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fabry's disease; Gaucher's disease type III; GM2 gangliosidoses; Polycystic kidney disease
  • Phase II Gaucher's disease
  • Discontinued Parkinson's disease

Most Recent Events

  • 19 Feb 2024 Sanofi announces intention to submit regulatory application for Gaucher's disease (type 3) in 2026 or later (Sanofi pipeline, February 2024)
  • 18 Apr 2022 Phase-III clinical trials in Gaucher's disease type III (In children, In adults, In the elderly) in USA (PO) (NCT05222906) (EudraCT2021-005402-10)
  • 10 Feb 2022 Sanofi plans to submit regulatory applications for Fabry's disease in 2025 or later (Sanofi pipeline, February 2022)

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