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Erdafitinib - Janssen Pharmaceutica

Drug Profile

Erdafitinib - Janssen Pharmaceutica

Alternative Names: BALVERSA; G-024; JNJ-42756493; JNJ-493; TAR-210

Latest Information Update: 24 Nov 2023

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At a glance

  • Originator Astex Therapeutics; Newcastle University
  • Developer Genentech; Janssen Pharmaceutica; Janssen Research & Development; Multiple Myeloma Research Consortium; National Cancer Institute (USA); University Health Network of Toronto; University of Washington; Vanderbilt-Ingram Cancer Center
  • Class Antineoplastics; Diamines; Pyrazoles; Quinoxalines; Small molecules
  • Mechanism of Action Fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Urogenital cancer
  • Phase II Bladder cancer; Cholangiocarcinoma; Gastric cancer; Multiple myeloma; Non-small cell lung cancer; Oesophageal cancer; Prostate cancer; Solid tumours
  • Phase I/II Liver cancer
  • No development reported Breast cancer; Lymphoma

Most Recent Events

  • 20 Nov 2023 Registered for Urogenital cancer (Inoperable/Unresectable, Second-line therapy or greater) (PO)
  • 22 Oct 2023 Efficacy and adverse events data from the phase I trial in bladder cancer released by the company
  • 21 Oct 2023 Efficacy and adverse events data from the phase 2 THOR-2 trial in bladder cancer released by the company
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