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OPB 111077

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Drug Profile

OPB 111077

Alternative Names: OPB-111077; OPC-317

Latest Information Update: 21 Mar 2024

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At a glance

  • Originator Korea Otsuka Pharmaceutical; Otsuka Pharmaceutical
  • Developer Korea Otsuka Pharmaceutical; Otsuka Pharmaceutical; Sidney Kimmel Cancer Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Signal transduction pathway inhibitors; STAT transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I Acute myeloid leukaemia; Diffuse large B cell lymphoma
  • No development reported Liver cancer

Most Recent Events

  • 04 Mar 2024 Otsuka America Pharmaceutical completes a phase I trial in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in USA (PO) (NCT03063944)
  • 09 Dec 2023 Efficacy and adverse events data from a phase I for Diffuse large B cell lymphoma presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
  • 16 Feb 2023 OPB 111077 is still in phase I for Diffuse large B cell lymphoma(Combination therapy, Second-line therapy or greater) in Japan (PO) (NCT04049825)

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