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Durvalumab - Celgene/MedImmune

Drug Profile

Durvalumab - Celgene/MedImmune

Alternative Names: Anti-PD-L1 monoclonal antibody; Anti-PD-LI mAb; Anti-programmed cell death 1 ligand 1 monoclonal antibody; Imfimzi; Imfinzi; MEDI-4736

Latest Information Update: 12 Oct 2021

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At a glance

  • Originator MedImmune
  • Developer Advaxis; AIO Studien gGmbH; AstraZeneca; AVEO Oncology; Big Ten Cancer Research Consortium; Biocompatibles International; Canadian Cancer Trials Group; Cancer Research UK; Case Comprehensive Cancer Center; Celgene International SARL; Centre hospitalier de l'Universite de Montreal; Centre Leon Berard; Charite - Universitatsmedizin Berlin; Childrens Hospital Los Angeles; Eli Lilly and Company; Fondazione IRCCS Istituto Nazionale dei Tumori; GlaxoSmithKline; Gradalis; Grand Hopital de Charleroi; Grupo Espanol de Tumores Neuroendocrinos; Gustave Roussy; Immunocore; Innate Pharma; Institut Claudius Regaud; Jules Bordet Institute; Juno Therapeutics; Kyoto Breast Cancer Research Network; Ludwig Institute for Cancer Research; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; Mirati Therapeutics; Myriad Genetic Laboratories; National Cancer Institute (USA); National Health and Medical Research Council; NHS Greater Glasgow and Clyde; Northwestern University; Pharmacyclics; Plexxikon; Radboud University; Samsung Medical Center; Spanish Oncology Genito-Urinary Group; Swiss Group for Clinical Cancer Research; UNC Lineberger Comprehensive Cancer Center; UNICANCER; University College London; University Health Network; University of Colorado at Denver; University of Kansas Medical Center; University of Maryland Greenbaum Cancer Center; University of Southern California; University of Sydney; University of Texas M. D. Anderson Cancer Center; VentiRx Pharmaceuticals; Washington University School of Medicine; Yale University; Yonsei University College of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer; Liver cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer; Small cell lung cancer
  • Registered Urogenital cancer
  • Phase III Biliary cancer; Bladder cancer; Cervical cancer; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Head and neck cancer; Liver cancer; Mesothelioma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma; Solid tumours
  • Phase II/III Pancreatic cancer
  • Phase II Acute myeloid leukaemia; Brain metastases; Breast cancer; Cholangiocarcinoma; Colorectal cancer; Diffuse large B cell lymphoma; Gallbladder cancer; Germ cell and embryonal neoplasms; Glioblastoma; Multiple myeloma; Myelodysplastic syndromes; Neuroendocrine tumours; Non-Hodgkin's lymphoma; Oropharyngeal cancer; Prostate cancer; Sarcoma; Soft tissue sarcoma; Uterine cancer
  • Phase I/II Chronic lymphocytic leukaemia; Cutaneous T-cell lymphoma; Haematological malignancies; Lung cancer; Lymphoma; Malignant melanoma; Peripheral T-cell lymphoma; Renal cancer
  • Phase I Gastrointestinal cancer; Vulvovaginal cancer
  • No development reported CNS cancer; Lymphoproliferative disorders; Thyroid cancer

Most Recent Events

  • 12 Oct 2021 AstraZeneca initiates a phase II ADMIRAL trial in Non-small cell lung cancer (Late-stage disease, Adjuvant therapy) in USA (IV) (NCT04372927)
  • 29 Sep 2021 AstraZeneca and Parexel plan the phase II NeoCOAST-2 trial for Non-small cell lung cancer (Neoadjuvant therapy, Adjuvant therapy, Early-stage disease, First-line therapy, Resectable, Combination therapy) (IV), in December 2021 (NCT05061550), (EudraCT2021-003369-37)
  • 17 Sep 2021 Efficacy and adverse events data from a phase II COAST trial in Non-small cell lung cancer presented at the European Society for Medical Oncology (ESMO) Congress 2021
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