Drug Profile


Alternative Names: Hafnium Oxide nanoparticles; NBTX 3; NBTXR-3; PEP-503

Latest Information Update: 29 Jun 2018

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At a glance

  • Originator Nanobiotix
  • Developer Nanobiotix; PharmaEngine; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Radiosensitisers
  • Mechanism of Action Free radical stimulants; Radiography enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Solid tumours

Highest Development Phases

  • Phase II/III Soft tissue sarcoma
  • Phase I/II Head and neck cancer; Prostate cancer; Rectal cancer
  • Preclinical Liver cancer; Lung cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 21 Jun 2018 Interim efficacy and adverse events data from a phase II/III act.in.sarc trial in Soft tissue sarcoma released by PharmaEngine and Nanobiotix
  • 01 Jun 2018 Updated efficacy and adverse events data from a phase I/II trial in liver cancer presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 17 Apr 2018 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the 109th Annual Meeting of the American Association for Cancer Research (AACR-2018)
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