Oremepermin alfa - Claris Biotherapeutics/Kringle Pharma
Alternative Names: CSB-001; Hepatocyte growth factor - Kringle Pharma; KP-100 - Kringle Pharma; KP-100IT; KP-100LILatest Information Update: 06 Aug 2026
At a glance
- Originator Kringle Pharma
- Developer Claris Biotherapeutics; Kringle Pharma
- Class Eye disorder therapies; Growth factors; Recombinant proteins
- Mechanism of Action Hepatocyte growth factor replacements
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Orphan Drug Status
Yes - Spinal cord injuries
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Scars; Spinal cord injuries
- Phase II Amyotrophic lateral sclerosis
- Phase I/II Neurotrophic keratopathy
- Phase I Acute kidney injury; Corneal injuries; Limbal stem cell deficiency
Most Recent Events
- 06 Aug 2026 Oremepermin alfa is still in phase I trial for Acute kidney injury in USA (Kringle Pharma pipeline, August 2026)
- 28 Jul 2026 Efficacy and adverse events data from a phase III trial in Spinal cord injuries released by Kringle Pharma
- 28 Jul 2026 Claris Biotherapeutics plans two pivotal clinical trials for Limbal stem cell deficiency in first half of 2027 (Ophthalmic)