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Oremepermin alfa - Claris Biotherapeutics/Kringle Pharma

Drug Profile

Oremepermin alfa - Claris Biotherapeutics/Kringle Pharma

Alternative Names: CSB-001; Hepatocyte growth factor - Kringle Pharma; KP-100 - Kringle Pharma; KP-100IT; KP-100LI

Latest Information Update: 06 Aug 2026

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At a glance

  • Originator Kringle Pharma
  • Developer Claris Biotherapeutics; Kringle Pharma
  • Class Eye disorder therapies; Growth factors; Recombinant proteins
  • Mechanism of Action Hepatocyte growth factor replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Spinal cord injuries
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Scars; Spinal cord injuries
  • Phase II Amyotrophic lateral sclerosis
  • Phase I/II Neurotrophic keratopathy
  • Phase I Acute kidney injury; Corneal injuries; Limbal stem cell deficiency

Most Recent Events

  • 06 Aug 2026 Oremepermin alfa is still in phase I trial for Acute kidney injury in USA (Kringle Pharma pipeline, August 2026)
  • 28 Jul 2026 Efficacy and adverse events data from a phase III trial in Spinal cord injuries released by Kringle Pharma
  • 28 Jul 2026 Claris Biotherapeutics plans two pivotal clinical trials for Limbal stem cell deficiency in first half of 2027 (Ophthalmic)

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