Research programme: antisense therapies - AstraZeneca/Ionis Pharmaceuticals

Drug Profile

Research programme: antisense therapies - AstraZeneca/Ionis Pharmaceuticals

Alternative Names: AZD 2693; AZD-2373; AZD-8233; IONIS-AZ4-2.5-LRx; IONIS-AZ5-2.5Rx; IONIS-AZ6-2.5-LRx; ISIS 581088

Latest Information Update: 12 Apr 2018

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At a glance

  • Originator Isis Pharmaceuticals
  • Developer AstraZeneca; Ionis Pharmaceuticals
  • Class Antineoplastics; Antisense oligonucleotides; Cardiovascular therapies; Hepatoprotectants
  • Mechanism of Action Androgen receptor antagonists; Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer; Cardiovascular disorders; Non-alcoholic steatohepatitis
  • Research Kidney disorders; Metabolic disorders

Most Recent Events

  • 20 Jul 2018 AstraZeneca and Parexel plan a phase I trial of AZD 8233 for Hypercholesterolaemia (In volunteers) in USA (SC), in July 2018 (NCT03593785),
  • 10 Apr 2018 Ionis Pharmaceuticals licenses IONIS-AZ6-2.5-LRx (AZD 2693) to AstraZeneca for development and commercialisation
  • 10 Apr 2018 Preclinical trials in Non-alcoholic steatohepatitis in USA (unspecified route) before April 2018
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