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Upadacitinib - AbbVie

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Drug Profile

Upadacitinib - AbbVie

Alternative Names: ABT-494; RINVOQ; RINVOQ LQ; Upadacitinib extended release - Abbvie; Upadacitinib modified release - Abbvie; Upadacitinib prolonged release - Abbvie; Upadacitinib tartrate; Upadicitinib hemihydrate - Abbvie

Latest Information Update: 06 Feb 2026

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At a glance

  • Originator Abbott Laboratories
  • Developer AbbVie
  • Class Amides; Anti-inflammatories; Antipsoriatics; Antirheumatics; Fluorocarbons; Imidazoles; Pyrazines; Pyrroles; Pyrrolidines; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Janus kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ankylosing spondylitis; Atopic dermatitis; Crohn's disease; Juvenile rheumatoid arthritis; Psoriatic arthritis; Rheumatoid arthritis; Ulcerative colitis
  • Registered Giant cell arteritis; Non-radiographic axial spondyloarthritis
  • Preregistration Vitiligo
  • Phase III Alopecia areata; Hidradenitis suppurativa; Systemic lupus erythematosus; Vasculitis

Most Recent Events

  • 03 Feb 2026 Preregistration for Vitiligo (In adolescents, In adults) in European Union (PO)
  • 03 Feb 2026 Preregistration for Vitiligo (In adolescents, In adults) in USA (PO)
  • 11 Nov 2025 AbbVie completes a phase III Measure Up 2 trial in Atopic dermatitis (In adolescents, In adults, In the elderly) in the US, Australia, Austria, Belgium, Bulgaria, Canada, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, South Korea, the Netherlands, New Zealand, Portugal, Singapore, Spain, Taiwan and the UK (NCT03607422)

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