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Upadacitinib - AbbVie

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Drug Profile

Upadacitinib - AbbVie

Alternative Names: ABT-494; RINVOQ; RINVOQ LQ; Upadacitinib extended release - Abbvie; Upadacitinib modified release - Abbvie; Upadacitinib prolonged release - Abbvie; Upadacitinib tartrate; Upadicitinib hemihydrate - Abbvie

Latest Information Update: 23 Dec 2025

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At a glance

  • Originator Abbott Laboratories
  • Developer AbbVie
  • Class Amides; Anti-inflammatories; Antipsoriatics; Antirheumatics; Fluorocarbons; Imidazoles; Pyrazines; Pyrroles; Pyrrolidines; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Janus kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ankylosing spondylitis; Atopic dermatitis; Crohn's disease; Juvenile rheumatoid arthritis; Psoriatic arthritis; Rheumatoid arthritis; Ulcerative colitis
  • Registered Giant cell arteritis; Non-radiographic axial spondyloarthritis
  • Phase III Alopecia areata; Hidradenitis suppurativa; Systemic lupus erythematosus; Vasculitis; Vitiligo

Most Recent Events

  • 11 Nov 2025 AbbVie completes a phase III Measure Up 2 trial in Atopic dermatitis (In adolescents, In adults, In the elderly) in the US, Australia, Austria, Belgium, Bulgaria, Canada, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, South Korea, the Netherlands, New Zealand, Portugal, Singapore, Spain, Taiwan and the UK (NCT03607422)
  • 29 Oct 2025 Efficacy and adverse event data from the phase III Viti-Up trial in Vitiligo released by AbbVie
  • 20 Oct 2025 Efficacy and adverse event data from a phase IIIb/IV SELECT-SWITCH trial in Rheumatoid arthritis released by AbbVie

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