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Upadacitinib - AbbVie

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Drug Profile

Upadacitinib - AbbVie

Alternative Names: ABT-494; RINVOQ; RINVOQ LQ; Upadacitinib extended release - Abbvie; Upadacitinib modified release - Abbvie; Upadacitinib prolonged release - Abbvie; Upadacitinib tartrate; Upadicitinib hemihydrate - Abbvie

Latest Information Update: 20 Jun 2025

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At a glance

  • Originator Abbott Laboratories
  • Developer AbbVie
  • Class Amides; Anti-inflammatories; Antipsoriatics; Antirheumatics; Fluorocarbons; Imidazoles; Pyrazines; Pyrroles; Pyrrolidines; Skin disorder therapies; Small molecules; Vascular disorder therapies
  • Mechanism of Action Janus kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ankylosing spondylitis; Atopic dermatitis; Crohn's disease; Juvenile rheumatoid arthritis; Psoriatic arthritis; Rheumatoid arthritis; Ulcerative colitis
  • Registered Giant cell arteritis; Non-radiographic axial spondyloarthritis
  • Phase III Alopecia areata; Hidradenitis suppurativa; Systemic lupus erythematosus; Vasculitis; Vitiligo

Most Recent Events

  • 16 Jun 2025 AbbVie plans to initiate a phase III trial for Alopecia Areata in Japan (PO) (NCT07023302)
  • 29 Apr 2025 Registered for Giant cell arteritis (Treatment-experienced, Combination therapy) in USA (PO)
  • 08 Apr 2025 Registered for Giant cell arteritis (Combination therapy, Treatment-experienced) in Liechtenstein, Iceland, European Union and Norway (PO, once daily)

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