Drug Profile

Promethazine/sumatriptan - Charleston Laboratories

Alternative Names: CL-H1T; sumatriptan succinate/promethazine HCl - Charleston Laboratories

Latest Information Update: 04 Feb 2026

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At a glance

Originator Charleston Laboratories
Class Amines; Antiemetics; Antimigraines; Indoles; Phenothiazines; Small molecules; Sulfonamides
Mechanism of Action Histamine H1 receptor antagonists; Muscarinic receptor antagonists; Serotonin 1D receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity No
Available For Licensing Yes

04 Feb 2026 Promethazine/sumatriptan is still in phase III trials for Migraine in USA (PO, Capsule)
04 Feb 2026 Promethazine/sumatriptan is still in phase III trials for Nausea and vomiting (Prevention) in USA (PO, Capsule)
21 Mar 2023 Promethazine/sumatriptan (CL H1T) is still in phase III trials for Migraine in USA (PO)

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