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Aldafermin - NGM Biopharmaceuticals

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Drug Profile

Aldafermin - NGM Biopharmaceuticals

Alternative Names: M 52; NGM 282

Latest Information Update: 14 Mar 2024

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At a glance

  • Originator NGM Biopharmaceuticals
  • Class Anti-inflammatories; Antifibrotics; Antihyperglycaemics; Hepatoprotectants; Laxatives; Recombinant proteins
  • Mechanism of Action FGF19 protein replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary sclerosing cholangitis; Primary biliary cirrhosis
  • New Molecular Entity No
  • Available For Licensing Yes - Non-alcoholic steatohepatitis

Highest Development Phases

  • Phase II Diarrhoea; Non-alcoholic steatohepatitis; Primary biliary cirrhosis; Primary sclerosing cholangitis
  • No development reported Constipation; Type 2 diabetes mellitus

Most Recent Events

  • 11 Mar 2024 NGM Biopharmaceuticals plans a registrational phase II trial for Primary Sclerosing Cholangitis in 2024
  • 09 Jan 2024 Aldafermin is still in phase II trials for Primary sclerosing cholangitis (Monotherapy, Combination therapy) in the US, United Kingdom, Netherlands, France
  • 10 Nov 2023 Efficacy and adverse event data from a phase IIb ALPINE 4 trial in Non alcoholic steatohepatitis presented at the 74th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2023)

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