NGM 282

Drug Profile

NGM 282

Alternative Names: NGM-282

Latest Information Update: 23 Nov 2017

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At a glance

  • Originator NGM Biopharmaceuticals
  • Class Antihyperglycaemics
  • Mechanism of Action Cholesterol 7 alpha hydroxylase inhibitors; Fibroblast growth factor receptor modulators; Type 1 fibroblast growth factor receptor modulators; Type 4 fibroblast growth factor receptor modulators; Type-2 fibroblast growth factor receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary biliary cirrhosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-alcoholic steatohepatitis; Primary biliary cirrhosis; Primary sclerosing cholangitis; Type 2 diabetes mellitus
  • Phase I/II Constipation

Most Recent Events

  • 20 Oct 2017 Interim efficacy and adverse events data from a clinical trial in Non-alcoholic steatohepatitis presented at the The Liver Meeting 2017: 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD-2017)
  • 20 Oct 2017 NGM Biopharmaceuticals initiates enrolment in the clinical trial for Non-alcoholic steatohepatitis in USA before October 2017
  • 19 Oct 2017 NGM Biopharmaceuticals initiates a phase II expansion trial for Non-alcoholic steatohepatitis
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