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Ulixertinib - BioMed Valley Discoveries

Drug Profile

Ulixertinib - BioMed Valley Discoveries

Alternative Names: BVD-523; BVD-523FB; BVD-ERK; BVD-ERK/HM; BVD-ERK/ST; VRT-0752271; VRT-752271; VX-271

Latest Information Update: 28 Apr 2019

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer BioMed Valley Discoveries; Dana-Farber Cancer Institute; National Cancer Institute (USA)
  • Class Aminopyridines; Antineoplastics; Pyrroles; Small molecules
  • Mechanism of Action Mitogen activated protein kinase 3 inhibitors; Mitogen-activated protein kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-Hodgkin's lymphoma; Solid tumours; Uveal melanoma
  • Phase I/II Acute myeloid leukaemia; Myelodysplastic syndromes
  • Phase I Pancreatic cancer

Most Recent Events

  • 28 Apr 2019 No recent reports of development identified for phase-I development in Pancreatic-cancer(Combination therapy, First-line therapy, Metastatic disease) in USA (PO)
  • 01 Oct 2018 Phase-II clinical trials in Non-Hodgkin's lymphoma (Recurrent, Second-line therapy or greater,In infants, In Children, Adolescents, In Adults) in USA (PO) (NCT03698994)
  • 01 Oct 2018 Phase-II clinical trials in Solid tumours (In infants, In Children, Adolescents, In Adults, Late-stage disease, Monotherapy) in USA (PO) (NCT03698994)
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