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Clostridium novyi-NT - BioMed Valley Discoveries

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Drug Profile

Clostridium novyi-NT - BioMed Valley Discoveries

Alternative Names: BVD-CNV; BVD-CNV/IT; BVD-CNV/IV; C.novyi-NT; Clostridium novyi-NT spores; Clostridium-novyi-non-toxic

Latest Information Update: 26 Jul 2018

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At a glance

  • Originator BioMed Valley Discoveries; Johns Hopkins University
  • Developer BioMed Valley Discoveries; M. D. Anderson Cancer Center; Merck Sharp & Dohme
  • Class Antineoplastics; Bacteria
  • Mechanism of Action Cell death stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 10 Jul 2018 Phase-I clinical trials in Solid tumours (Combination therapy, Second-line therapy or greater, Late-stage disease) in USA (Intratumoural) (NCT03435952)
  • 28 May 2018 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Second-line therapy or greater) in USA (Intratumoural, Injection)
  • 16 Feb 2018 BioMed Valley Discoveries and Merck & Co. plan a phase Ib trial of pembrolizumab in combination with for intratumoral Injection of Clostridium Novyi-NT Solid tumours (Combination therapy, Second-line therapy or greater, Late-stage disease) in the US (NCT03435952)
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