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PHP 303

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Drug Profile

PHP 303

Alternative Names: BAY 858501; PHP-303

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Bayer HealthCare
  • Developer Akari Therapeutics; Bayer HealthCare
  • Class Antibronchitics; Benzenesulfonates; Fluorinated hydrocarbons; Hepatoprotectants; Nitriles; Pyrimidines; Small molecules
  • Mechanism of Action Leucocyte elastase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Alpha 1-antitrypsin deficiency
  • No development reported Adult respiratory distress syndrome; Non-alcoholic steatohepatitis
  • Discontinued Bronchiectasis

Most Recent Events

  • 28 Jul 2026 No recent reports of development identified for preclinical development in Adult-respiratory-distress-syndrome in USA (PO, Tablet)
  • 14 Nov 2024 Peak Bio has merged with Akari Therapeutics to form Akari Therapeutics
  • 25 Jul 2024 Discontinued - Phase-II for Bronchiectasis (Non-cystic fibrosis-related) in France (PO)

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