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Esketamine - Johnson & Johnson

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Drug Profile

Esketamine - Johnson & Johnson

Alternative Names: Esketamine nasal spray; JNJ-54135419; JNJ-54135419-AAA; JNJ-5419; S-ketamine; SPRAVATO

Latest Information Update: 18 Nov 2025

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At a glance

  • Originator Johnson & Johnson
  • Class Analgesics; Antidepressants; Chlorobenzenes; Cyclohexanones; General anaesthetics; Small molecules
  • Mechanism of Action NMDA receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Major depressive disorder

Most Recent Events

  • 12 Nov 2025 Janssen Research & Development plans the phase III AVENUE trial for Major depressive disorder (In adolescents, Adjunctive treatment) (Intranasal), in November 2025 , (NCT07227454)
  • 21 Jan 2025 Registered for Major depressive disorder (Monotherapy, Treatment-resistant) in USA (Intranasal)
  • 22 Jul 2024 Preregistration for Major depressive disorder (Treatment-resistant, Monotherapy) in USA (Intranasal)

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