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Bryostatin 1 - Synaptogenix

Drug Profile

Bryostatin 1 - Synaptogenix

Alternative Names: Bryostatin-1 - Neurotrope; MW-904

Latest Information Update: 02 Jul 2024

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At a glance

  • Originator Blanchette Rockefeller Neurosciences Institute; Neurotrope BioScience
  • Developer Blanchette Rockefeller Neurosciences Institute; National Cancer Institute (USA); National Institute on Aging; Rettsyndrome.org; Synaptogenix
  • Class Antidementias; Antidepressants; Antineoplastics; Antiparkinsonians; Behavioural disorder therapies; Macrocyclic compounds; Small molecules; Vascular disorder therapies
  • Mechanism of Action Protein kinase C stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fragile X syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease
  • Phase I Multiple sclerosis
  • Preclinical Pervasive child development disorders
  • No development reported Depressive disorders; Fragile X syndrome; Niemann-Pick disease type C; Parkinson's disease; Rett syndrome; Stroke; Traumatic brain injuries

Most Recent Events

  • 27 Jun 2024 US FDA approves IND application for Bryostatin-1 in Multiple sclerosis
  • 11 Apr 2024 Phase-I clinical trials in Multiple sclerosis in USA (IV) (NCT06190912)
  • 19 Dec 2023 Updated efficacy data from a phase IIb trial in Alzheimer's disease released by Synaptogenix

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