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Etrasimod - Pfizer

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Drug Profile

Etrasimod - Pfizer

Alternative Names: APD-334; Etrasimod arginine - Pfizer; PF-07915503; VELSIPITY

Latest Information Update: 26 Jul 2024

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At a glance

  • Originator Arena Pharmaceuticals
  • Developer Arena Pharmaceuticals; Everest Medicines; Pfizer
  • Class 3-ring heterocyclic compounds; Acetic acids; Amino acids; Anti-inflammatories; Benzene derivatives; Cyclopentanes; Ethers; Fluorinated hydrocarbons; Indoles; Skin disorder therapies; Small molecules
  • Mechanism of Action Sphingosine 1 phosphate receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Eosinophilic oesophagitis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ulcerative colitis
  • Phase II/III Atopic dermatitis; Crohn's disease
  • Phase II Eosinophilic oesophagitis
  • Discontinued Alopecia areata; Inflammatory bowel diseases; Primary biliary cirrhosis; Pyoderma gangrenosum

Most Recent Events

  • 30 May 2024 Pfizer terminates phase II/III clinical trials in Atopic dermatitis (Treatment-resistant) in USA, Canada, Czech Republic, Poland (PO), due to efficacy reasons only and is not due to any safety concerns (NCT05732454)
  • 22 May 2024 Registered for Ulcerative colitis (Treatment-resistant) in Australia (PO)
  • 24 Apr 2024 Pfizer granted a Notice of Compliance (NOC) from Health Canada for VELSIPITY™ in Ulcerative Colitis (UC) in Canada
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