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Research programme: small molecule therapeutics - Syros Pharmaceuticals

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Drug Profile

Research programme: small molecule therapeutics - Syros Pharmaceuticals

Alternative Names: CDK 11 inhibitors; CDK12 inhibitor; CDK12/12 inhibitors - Syros Pharmaceuticals; Cyclin-dependent kinase 12/13 inhibitors - Syros Pharmaceuticals; SY 351; SY-12882; THZ1; THZ531; WRN inhibitors

Latest Information Update: 21 Aug 2023

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At a glance

  • Originator Syros Pharmaceuticals
  • Developer Dana-Farber Cancer Institute; Syros Pharmaceuticals; Whitehead Institute for Biomedical Research
  • Class Antianaemics; Antidementias; Antineoplastics; Small molecules; Urologics
  • Mechanism of Action Cyclin-dependent kinase inhibitors; Cyclin-dependent kinase-activating kinase inhibitors; Gene expression modulators; Immunosuppressants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • No development reported Acute myeloid leukaemia; Alzheimer's disease; Autoimmune disorders; Cancer; Ewing's sarcoma; Neuroblastoma; Ovarian cancer; Polycystic kidney disease; Precursor cell lymphoblastic leukaemia-lymphoma; Sickle cell anaemia; Small cell lung cancer; Triple negative breast cancer

Most Recent Events

  • 02 Jun 2023 Pharmacodynamics data from a preclinical trial in Colorectal cancer presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 28 Dec 2022 No recent reports of development identified for preclinical development in Cancer in USA (PO)
  • 26 Oct 2022 Pharmacodynamics data from a preclinical trial in Cancer presented at the 34th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics (EORTC-NCI-AACR-2022)
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