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LB 100

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Drug Profile

LB 100

Alternative Names: LB-1; LB-100

Latest Information Update: 28 Sep 2025

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At a glance

  • Originator Lixte Biotechnology Holdings
  • Developer City of Hope National Medical Center; Grupo Espanol de Investigacion en Sarcomas; INSERM; Lixte Biotechnology Holdings; M. D. Anderson Cancer Center; National Cancer Institute (USA)
  • Class Anti-ischaemics; Antidepressants; Antineoplastics; Behavioural disorder therapies; Carboxylic acids; Heterocyclic bicyclo compounds; Piperazines; Small molecules
  • Mechanism of Action Protein phosphatase 2A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Breast cancer

Highest Development Phases

  • Phase II Glioblastoma
  • Phase I/II Myelodysplastic syndromes; Ovarian cancer; Soft tissue sarcoma
  • Phase I Colorectal cancer
  • No development reported Angelman syndrome; Behavioural disorders; Ischaemia; Small cell lung cancer; Solid tumours
  • Discontinued Depressive disorders; Haematological disorders

Most Recent Events

  • 28 Sep 2025 No recent reports of development identified for preclinical development in Behavioural-disorders in USA
  • 09 Jul 2025 Lixte Biotechnology and GSK enters into a research collaboration for a clinical trial in Ovarian cancer
  • 06 Sep 2024 LIXTE Biotechnology has patent protection for combining the LB 100 compound with various innovative cancer immunotherapies in USA

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