NUC 1031

Drug Profile

NUC 1031

Alternative Names: Acelarin®; CPF-31; Gemzar ProTide - NuCana; MTL-007; NUC-1031

Latest Information Update: 23 Jan 2018

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At a glance

  • Originator Cardiff University
  • Developer Imperial College of Science, Technology and Medicine; NuCana
  • Class Antineoplastics
  • Mechanism of Action DNA synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pancreatic cancer
  • Phase II Ovarian cancer
  • Phase I/II Solid tumours
  • Phase I Biliary cancer; Bladder cancer; Non-small cell lung cancer

Most Recent Events

  • 19 Jan 2018 Interim efficacy and adverse events data from a phase Ib trial in Biliary tract cancer presented at the 2018 American Society of Clinical Oncology Gastrointestinal Cancer Symposium (ASCO-GCS-2018)
  • 19 Jan 2018 NuCana plans to initiate a phase III trial for Biliary tract cancer (Late-stage disease, Combination therapy) in 2018
  • 28 Dec 2017 No recent reports of development identified for phase-I development in Ovarian-cancer(Combination therapy, Recurrent) in United Kingdom (IV, Injection)
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