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Berzosertib - Merck KGaA

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Drug Profile

Berzosertib - Merck KGaA

Alternative Names: Captisol® enabled VX 970; M-6620; MSC 2527093A; VX-970

Latest Information Update: 08 Jul 2026

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer EMD Serono Research & Development Institute; Massachusetts General Hospital; Merck KGaA; National Cancer Institute (USA); University of Oxford
  • Class Amines; Antineoplastics; Isoxazoles; Pyrazines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action ATR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fallopian tube cancer; Gastric cancer; Leiomyosarcoma; Ovarian cancer; Peritoneal cancer; Prostate cancer; Small cell lung cancer; Solid tumours; Urogenital cancer
  • Preclinical Triple negative breast cancer
  • No development reported Acute myeloid leukaemia; Head and neck cancer; Oesophageal cancer

Most Recent Events

  • 22 Apr 2026 Pharmacodynamics data from a preclinical trials in Triple-negative-breast-cancer presented at the 17th Annual Meeting of the American Association for Cancer Research(AACR-2026)
  • 21 Apr 2026 Institut Bergonié in collaboration with Merck Healthcare KGaA completes the Phase II TARSARC trial in Leiomyosarcoma (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/unresectable, Second-line therapy or greater) in France (IV) (NCT04807816)
  • 17 Apr 2026 Preclinical trials in Triple-negative-breast-cancer in USA (IV)

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