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Berzosertib - Merck KGaA

Drug Profile

Berzosertib - Merck KGaA

Alternative Names: Captisol® enabled VX 970; M6620; VX-970

Latest Information Update: 26 Nov 2019

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer EMD Serono Research & Development Institute; Massachusetts General Hospital; Merck KGaA; National Cancer Institute (USA); University of Oxford
  • Class Amines; Antineoplastics; Isoxazoles; Pyrazines; Radiation-sensitising agents; Small molecules
  • Mechanism of Action ATR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Small cell lung cancer; Solid tumours; Urogenital cancer
  • Phase I Breast cancer; Non-small cell lung cancer; Oesophageal cancer
  • Preclinical Acute myeloid leukaemia

Most Recent Events

  • 14 Nov 2019 Phase-II clinical trials in Small cell lung cancer (Combination therapy, Second-line therapy or greater) in USA (IV) (NCT04162041)
  • 06 Nov 2019 EMD Serono and Merck complete a phase II trial in Ovarian cancer, Fallopian tube cancer and Peritoneal cancer in the UK, USA and Belgium (IV) (NCT03704467)
  • 14 Aug 2019 National Cancer Institute plans a phase I trial for Breast cancer in November 2019 (NCT04052555)
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