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Andecaliximab - Gilead Sciences

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Drug Profile

Andecaliximab - Gilead Sciences

Alternative Names: Anti-matrix metalloproteinase-9 monoclonal antibody; Anti-MMP9 monoclonal antibody; GS-5745

Latest Information Update: 30 Jun 2025

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At a glance

  • Originator Gilead Sciences
  • Developer ashibio; Gilead Sciences
  • Class Antineoplastics; Antiulcers; Monoclonal antibodies
  • Mechanism of Action Matrix metalloproteinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibrodysplasia ossificans progressiva
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Fibrodysplasia ossificans progressiva
  • Discontinued Chronic obstructive pulmonary disease; Crohn's disease; Cystic fibrosis; Gastric cancer; Glioblastoma; Rheumatoid arthritis; Solid tumours; Ulcerative colitis

Most Recent Events

  • 14 May 2025 Ashibio initiates phase-I/II ANDECA-HO clinical trials in Fibrodysplasia ossificans progressiva in USA (SC) (NCT07024407)
  • 23 Jan 2025 US FDA grantes a Rare Pediatric Disease Designation (RPDD) to Andecaliximab in Fibrodysplasia Ossificans Progressive, before January 2025
  • 25 Oct 2024 Phase-II/III clinical trials in Fibrodysplasia ossificans progressiva in USA (SC) (NCT06508021)

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