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Cal 1

Drug Profile

Cal 1

Alternative Names: Autologous CD34+ Haematopoietic Stem/Progenitor Cells + CD4+ T Lymphocytes Transduced with LVsh5/C46 - Calimmune; Cal 1 therapy; Cal 1-modified HSPC; Cal 1-transduced haematopoietic stem progenitor cells; Cal-1; Cal-1-Calimmune; Cal-1-transduced-haematopoietic-stem-progenitor-cells-Calimmune; Dual Anti-HIV Gene Transfer Construct; LVsh5/C46-transduced-HSPC; LVsh5C46; LVsh5C46-transduced-HSPC

Latest Information Update: 05 Mar 2019

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At a glance

  • Originator Calimmune
  • Developer Assistance Publique Hopitaux de Paris; Calimmune
  • Class Antivirals; Cell therapies; Gene therapies
  • Mechanism of Action Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II HIV-1 infections

Most Recent Events

  • 15 Jan 2019 Phase-I/II clinical trials in HIV-1 infections in France (IV) (NCT03593187)
  • 20 Jul 2018 CSL Behring plans the phase I/II GENHIV trial for HIV-1 Infections in France (IV) (NCT03593187)
  • 01 Nov 2017 Calimmune completes a phase I/II trial in HIV-1 infections in USA (NCT01734850)
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