Atabecestat - Janssen Pharmaceuticals

Drug Profile

Atabecestat - Janssen Pharmaceuticals

Alternative Names: JNJ-54861911

Latest Information Update: 15 Jun 2018

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At a glance

  • Originator Shionogi
  • Developer Janssen Research & Development
  • Class Amides; Antidementias; Small molecules; Thiazines
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease

Most Recent Events

  • 04 Jun 2018 Chemical structure information added
  • 25 May 2018 Janssen Research & Development terminates a phase II/III trial in Alzheimer's disease (In the elderly, In adults) in USA, Australia, Belgium, Canada, Denmark, Finland, France, Germany, Italy, Japan, Mexico, the Netherlands, Spain, Sweden, Switzerland, and the United Kingdom (PO) due to high elevations of liver enzymes in patients placing them at increased risk for severe liver injury
  • 25 May 2018 Janssen suspends patient enrolment in the phase II/III DIAN-TU trial for Alzheimer's disease (Early-stage disease) in USA, United Kingdom, Spain and Italy to explore options to improve the benefit / risk for these patients (PO)
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