Drug Profile

Catequentinib - Advenchen Laboratories/Jiangsu Chia Tai Tianqing Pharmaceutical

Alternative Names: AL-3818; ALTN; Anlotinib; Anlotinib hydrochloride; Anrotinib; FOCUS V

Latest Information Update: 25 Sep 2025

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At a glance

Originator Advenchen Laboratories; Jiangsu Chia-Tai Tianqing Pharmaceutical
Developer Advenchen Laboratories; Akeso Biopharma; Chia Tai Tianqing Pharmaceutical Group; Henan Cancer Hospital; Peking University People's Hospital
Class Amines; Antineoplastics; Cyclopropanes; Ethers; Fluorinated hydrocarbons; Indoles; Quinolines; Small molecules
Mechanism of Action Fibroblast growth factor receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists; Vascular endothelial growth factor receptor-3 antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Ovarian cancer; Soft tissue sarcoma
New Molecular Entity Yes

Marketed Medullary thyroid cancer; Non-small cell lung cancer; Small cell lung cancer; Soft tissue sarcoma; Thyroid cancer
Preregistration Endometrial cancer
Phase III Alveolar soft part sarcoma; Colorectal cancer; Gastric cancer; Leiomyosarcoma; Liver cancer; Nasopharyngeal cancer; Synovial sarcoma
Phase II Bone cancer; Cancer; Cervical cancer; Cholangiocarcinoma; Ewing's sarcoma; Fallopian tube cancer; Gastrointestinal cancer; Gastrointestinal stromal tumours; Glioblastoma; Head and neck cancer; Neuroendocrine tumours; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Renal cell carcinoma; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
Phase I/II Acral lentiginous melanoma
No development reported Solid tumours

25 Sep 2025 Efficacy and adverse event data from phase III trial in Non-small cell lung cancer presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)
04 Jun 2025 Chia Tai Tianqing Pharmaceutical Group terminates a phase-Ib trial in Liver cancer (First-line therapy, Combination therapy, Late-stage disease) in China (IV) (NCT05975645) due to business reasons, but no safety and efficacy concerns
30 May 2025 Efficacy and adverse events data from a phase III trial in Soft tissue sarcoma presented at the 61^st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)

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