Research programme: alpha-emitting monoclonal antibody radiopharmaceuticals - Actinium Pharmaceuticals

Drug Profile

Research programme: alpha-emitting monoclonal antibody radiopharmaceuticals - Actinium Pharmaceuticals

Alternative Names: AA-A225; Ac-225 labeled anti-A33 monoclonal antibody; Ac-225-labeled anti-CD45 monoclonal antibody; Ac-255 labeled AA; Actimab-B; Actimab-Br; Actimab-C; Actimab-P; Actinium-225 labeled daratumumab; anti-A33 monoclonal antibody Ac-225; anti-CD45 monoclonal antibody BC8-Ac-225

Latest Information Update: 16 Apr 2018

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At a glance

  • Originator Fred Hutchinson Cancer Research Center
  • Developer Actinium Pharmaceuticals; Memorial Sloan-Kettering Cancer Center
  • Class Drug conjugates; Immunoconjugates; Monoclonal antibodies; Radiopharmaceuticals
  • Mechanism of Action Angiogenesis inhibitors; Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Brain cancer; Colorectal cancer; Haematological malignancies; Multiple myeloma; Prostate cancer

Most Recent Events

  • 11 Apr 2018 Pharmacodynamics data from a preclinical trial in Multiple myeloma released by Actinium Pharmaceuticals
  • 12 Mar 2018 Preclinical development for Prostate cancer and Colorectal cancer is ongoing (Actinium Pharmaceuticals pipeline, March 2018)
  • 12 Mar 2018 Preclinical trials in Brain cancer in USA (Parenteral) (Actinium Pharmaceuticals pipeline, March 2018)
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