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Sonelokimab - MoonLake Immunotherapeutics

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Drug Profile

Sonelokimab - MoonLake Immunotherapeutics

Alternative Names: ALX 0761; Anti-IL-17A/F Nanobody; M 1095; MSB-0010841; Nanobody® IL-17 A/F inhibitor; Sonelokinab

Latest Information Update: 01 Oct 2025

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At a glance

  • Originator Ablynx
  • Developer Avillion; MoonLake Immunotherapeutics
  • Class Anti-inflammatories; Antipsoriatics; Antirheumatics; Single-domain antibodies; Skin disorder therapies
  • Mechanism of Action IL17A protein inhibitors; IL17F protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hidradenitis suppurativa; Psoriatic arthritis
  • Phase II Axial spondyloarthritis; Palmoplantar pustulosis; Psoriasis
  • No development reported Ankylosing spondylitis

Most Recent Events

  • 28 Sep 2025 Interim efficacy and adverse events data from the phase III VELA-1 and VELA-2 trial in Hidradenitis suppurativa released by MoonLake Immunotherapeutics
  • 05 Aug 2025 MoonLake Immunotherapeutics announces intention to launch sonelokimab in 2027
  • 05 Aug 2025 MoonLake Immunotherapeutics announces intention to submit the BLA to the US FDA for Hidradenitis suppurativa in mid-2026

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