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Drug Profile

Deupirfenidone - PureTech Health

Alternative Names: Deuterated pirfenidone; Deuterium-substituted pirfenidone; LYT-100; LYT-100-COV; LYT-100-ILD; LYT-100-LYMPH; Pirfenidone deuterated; SD-560

Latest Information Update: 19 Dec 2024

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At a glance

  • Originator Auspex Pharmaceuticals
  • Developer PureTech Health
  • Class Anti-infectives; Anti-inflammatories; Antifibrotics; Organic deuterium compounds; Pyridones; Small molecules
  • Mechanism of Action Collagen inhibitors; Cytokine inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Idiopathic pulmonary fibrosis
  • Discontinued Lymphoedema; Post acute COVID 19 syndrome

Most Recent Events

  • 16 Dec 2024 Efficacy and safety data from the phase IIb ELEVATE trial in Idiopathic pulmonary fibrosis released by PureTech Health
  • 01 Dec 2024 PureTech plans a phase I Drug-drug interaction trial in Healthy volunteers (Combination therapy) in December 2024 (NCT06717100)
  • 16 Apr 2024 PureTech Health completes enrollment in a phase IIb ELEVATE trial in Idiopathic pulmonary fibrosis (Treatment-naive) in USA, Argentina, Chile, Colombia, Georgia, Greece, India, South Korea, Malaysia, Mexico, Philippines, Romania, South Africa, and Thailand (PO) (NCT05321420)

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