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Deupirfenidone - Celea Therapeutics

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Drug Profile

Deupirfenidone - Celea Therapeutics

Alternative Names: Deuterated pirfenidone; Deuterium-substituted pirfenidone; LYT-100; LYT-100-COV; LYT-100-ILD; LYT-100-LYMPH; Pirfenidone deuterated; SD-560

Latest Information Update: 11 Dec 2025

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At a glance

  • Originator Auspex Pharmaceuticals
  • Developer PureTech Health
  • Class Anti-infectives; Anti-inflammatories; Antifibrotics; Organic deuterium compounds; Pyridones; Small molecules
  • Mechanism of Action Collagen inhibitors; Cytokine inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Idiopathic pulmonary fibrosis
  • Discontinued Lymphoedema; Post acute COVID 19 syndrome

Most Recent Events

  • 08 Dec 2025 PureTech plans registration enabling phase III SURPASS-IPF trial for Idiopathic pulmonary fibrosis in USA (PO) in the first half of 2026
  • 22 Oct 2025 Updated adverse event data from the phase IIb ELEVATE IPF trial in Idiopathic pulmonary disease released by PureTech Health
  • 29 Sep 2025 Updated efficacy and adverse events data from a phase IIb ELEVATE IPF trial in Idiopathic pulmonary fibrosis released by PureTech

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