GSK 3377794

Drug Profile

GSK 3377794

Alternative Names: GSK-3377794; NY-ESO SPEAR T-cell therapy; NY-ESO TCR therapeutic; NY-ESO-1 T cell receptor; NY-ESO-1-specific T-cells - Adaptimmune; NY-ESO-1/LAGE-1-modified T-cells; NY-ESO-1c259T; NY-ESO-c259T

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Adaptimmune
  • Developer Adaptimmune; GlaxoSmithKline; Merck & Co
  • Class Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Synovial sarcoma
  • New Molecular Entity No

Highest Development Phases

  • Phase II Gastrointestinal cancer; Malignant melanoma; Multiple myeloma; Ovarian cancer
  • Phase I/II Liposarcoma; Non-small cell lung cancer; Synovial sarcoma
  • No development reported Liver cancer; Prostate cancer

Most Recent Events

  • 15 Mar 2018 Efficacy data from a phase I/II trial in Liposarcoma released by Adaptimmune
  • 11 Dec 2017 Adverse events and efficacy data from a phase I/II pivotal trial in Multiple myeloma presented at the American Society of Hematology Annual Meeting (ASH-2017)
  • 05 Dec 2017 Updated efficacy and adverse events data from a phase I/II trial in Multiple myeloma released by Adaptimmune
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