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Drug Profile


Alternative Names: GUT-1; MT-5745; STNM 01

Latest Information Update: 30 Nov 2023

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At a glance

  • Originator Stelic Institute & Co
  • Developer Gut; Sameshima Hospital; Stelic Institute & Co
  • Class Anti-inflammatories; Antifibrotics; Antiulcers
  • Mechanism of Action RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ulcerative colitis
  • Phase I Crohn's disease

Most Recent Events

  • 14 Oct 2023 GUT 1 is still in phase II trials for Ulcerative colitis in Japan
  • 14 Oct 2023 Safety and efficacy data from a phase I trial in Ulcerative colitis presented at the 31st United European Gastroenterology Week 2023 (UEGW-2023)
  • 12 May 2021 Stelic Institute discontinues a phase I clinical trial for Ulcerative colitis and Crohn's disease (Treatment-experienced) in Japan (Submucosal) (UMIN000020900)
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