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sEphB4-HSA - VasGene Therapeutics

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Drug Profile

sEphB4-HSA - VasGene Therapeutics

Alternative Names: EphB4-HSA; EphB4-Human Serum Albumin; Human Serum Albumin-EphB4 conjugate; Recombinant EphB4-HSA Fusion Protein; Vas 01

Latest Information Update: 28 Apr 2025

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At a glance

  • Originator VasGene Therapeutics
  • Developer National Cancer Institute (USA); University of Southern California; VasGene Therapeutics
  • Class Antineoplastics; Recombinant fusion proteins
  • Mechanism of Action EphB4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Bladder cancer; Urogenital cancer
  • Phase II Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Head and neck cancer; Kaposi's sarcoma; Myelodysplastic syndromes; Non-small cell lung cancer; Prostate cancer; Solid tumours
  • No development reported Leukaemia; Renal cancer

Most Recent Events

  • 15 Mar 2025 Phase-II/III clinical trials in Bladder cancer (Combination therapy) in USA (IV) (NCT06493552)
  • 15 Mar 2025 Phase-II/III clinical trials in Urogenital cancer (Combination therapy, Metastatic disease) in USA (IV) (NCT06493552)
  • 19 Feb 2025 Vasgene Therapeutics and AIDS Malignancy Consortium completes a phase II trial in Kaposi's sarcoma in USA (NCT02799485)

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