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Avasopasem manganese - Galera Therapeutics

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Drug Profile

Avasopasem manganese - Galera Therapeutics

Alternative Names: Avasopasem; GC 4419

Latest Information Update: 03 Sep 2025

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At a glance

  • Originator Galera Therapeutics
  • Class Anti-inflammatories; Antifibrotics; Antineoplastics; Aza compounds; Chemoprotectants; Cyclohexanes; Pyridines; Small molecules
  • Mechanism of Action Antioxidants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II HER2 negative breast cancer
  • Suspended COVID 2019 infections; Head and neck cancer; Mucositis; Oesophagitis; Pancreatic cancer; Stomatitis; Unspecified
  • Discontinued Fibrosis

Most Recent Events

  • 22 Aug 2025 University of Texas Health Science Center at San Antonio plans a phase I trial for HER2-negative-breast-cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (unspecified), in September 2025 , (NCT07137871)
  • 03 Jan 2025 Phase-Ib/IIa clinical trials in HER2- negative breast cancer (Metastatic disease, Combination therapy) in USA (unspecified route) (Galera Therapeutics pipeline, January 2025)
  • 31 Dec 2024 Galera Therapeutics plans a clinical trial for HER2- negative breast cancer (Second-line therapy or greater, Late-stage disease) in first half of 2025

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