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Narsoplimab - Omeros Corporation

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Drug Profile

Narsoplimab - Omeros Corporation

Alternative Names: anti-MASP-2 monoclonal antibody; MASP-2 antibody - Omeros Corporation; MASP-2 therapeutic; Narsoplimab-wuug - Omeros Corporation; OMS 00620646; OMS 620646; OMS 721; YARTEMLEA

Latest Information Update: 31 Dec 2025

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At a glance

  • Originator Omeros Corporation
  • Class Anti-inflammatories; Antithrombotics; Eye disorder therapies; Monoclonal antibodies; Urologics; Vascular disorder therapies
  • Mechanism of Action MASP2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - IgA nephropathy; Thrombotic microangiopathies
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Registered Thrombotic microangiopathies
  • Phase II COVID 2019 infections
  • Preclinical Adult respiratory distress syndrome
  • Discontinued Glomerulonephritis; Haemolytic uraemic syndrome; IgA nephropathy; Lupus nephritis; Membranous glomerulonephritis; Stroke; Wet age-related macular degeneration

Most Recent Events

  • 24 Dec 2025 Omeros Corporation plans to launch Narsoplimab for Thrombotic microangiopathies in USA in January 2026
  • 24 Dec 2025 Pooled efficacy and adverse events data from the phase II OMS721-TMA-001 pivotal trial and Expanded access programme in Thrombotic microangiopathies released by Omeros Corporation
  • 24 Dec 2025 Registered for Thrombotic microangiopathies (In children, In adolescents, In adults) in USA (IV) - First Global Approval

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