OMS 721

Drug Profile

OMS 721

Alternative Names: anti-MASP-2 monoclonal antibody; MASP-2 antibody - Omeros Corporation; MASP-2 therapeutic; OMS 00620646; OMS 620646; OMS-721

Latest Information Update: 08 Mar 2018

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At a glance

  • Originator Omeros Corporation
  • Class Anti-inflammatories; Antithrombotics; Monoclonal antibodies
  • Mechanism of Action MASP2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thrombotic microangiopathies; IgA nephropathy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Haemolytic uraemic syndrome; IgA nephropathy; Thrombotic microangiopathies
  • Phase II Glomerulonephritis; Lupus nephritis; Membranous glomerulonephritis
  • No development reported Stroke; Wet age-related macular degeneration

Most Recent Events

  • 15 Feb 2018 Phase-III clinical trials in IgA nephropathy in USA (Parenteral)
  • 15 Feb 2018 Phase-III clinical trials in Thrombotic microangiopathies in USA (IV)
  • 15 Feb 2018 Omeros schedules meetings with the US FDA and the European Medicines Agency to discuss the most expeditious path to approval for OMS 721 in haematopoietic stem cell transplant-associated Thrombotic microangiopathy
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