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Astegolimab - Genentech

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Drug Profile

Astegolimab - Genentech

Alternative Names: AMG-282; Anti-ST2; MSTT 1041 A; RG 6149; RO 7187807; ST2 MAb

Latest Information Update: 10 May 2024

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At a glance

  • Originator Amgen
  • Developer Amgen; Genentech; Roche; University of Leicester
  • Class Anti-inflammatories; Antiallergics; Antiasthmatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin-33 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic obstructive pulmonary disease
  • Phase II Allergic asthma; Atopic dermatitis
  • Discontinued Asthma; COVID-19 pneumonia; Rhinosinusitis

Most Recent Events

  • 09 May 2024 Roche plans to submit regulatory fillings in Chronic obstructive pulmonary disease, in 2025 (Roche pipeline, May 2024)
  • 09 Sep 2023 Updated efficacy data from a phase II trial in Chronic obstructive pulmonary disease presented at the 33rd Annual Congress of the European Respiratory Society (ERS-2023)
  • 28 Jun 2023 Roche initiates a phase III trial for Chronic obstructive pulmonary disease in USA (SC) (NCT05878769)
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