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Pelabresib - MorphoSys

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Drug Profile

Pelabresib - MorphoSys

Alternative Names: CPI-0610; DAK-539

Latest Information Update: 28 Aug 2026

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At a glance

  • Originator Constellation Pharmaceuticals
  • Developer Constellation Pharmaceuticals; MorphoSys; The Leukemia & Lymphoma Society
  • Class Amides; Antihaemorrhagics; Antineoplastics; Benzazepines; Chlorinated hydrocarbons; Oxazoles; Small molecules
  • Mechanism of Action Bromodomain and extra-terminal domain protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myelofibrosis
  • Phase II Essential thrombocythaemia; Leukaemia; Myelodysplastic syndromes
  • No development reported Haematological malignancies; Solid tumours
  • Discontinued Lymphoma; Multiple myeloma

Most Recent Events

  • 24 Aug 2026 Novartis Pharmaceuticals plans a phase I pharmacokinetics trial in Healthy volunteers (PO) in August 2026 (NCT07783503)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Haematological-malignancies(Late-stage disease) in Georgia (PO)
  • 28 Jul 2026 No recent reports of development identified for phase-I development in Haematological-malignancies(Late-stage disease) in Spain (PO)

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