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Pelabresib - MorphoSys

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Drug Profile

Pelabresib - MorphoSys

Alternative Names: CPI-0610; DAK-539

Latest Information Update: 26 Feb 2026

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At a glance

  • Originator Constellation Pharmaceuticals
  • Developer Constellation Pharmaceuticals; MorphoSys; The Leukemia & Lymphoma Society
  • Class Amides; Antihaemorrhagics; Antineoplastics; Benzazepines; Chlorinated hydrocarbons; Oxazoles; Small molecules
  • Mechanism of Action Bromodomain and extraterminal domain protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myelofibrosis
  • Phase II Essential thrombocythaemia; Leukaemia; Myelodysplastic syndromes
  • No development reported Haematological malignancies; Solid tumours
  • Discontinued Lymphoma; Multiple myeloma

Most Recent Events

  • 20 Feb 2026 Novartis plans a phase Ib trial for Haematological malignancies (Late-stage disease) and Liver disorders (PO, Once daily), in May 2026 (CTIS2025-521001-40-00), (NCT07422610)
  • 22 Jan 2026 Novartis Pharmaceuticals plans a phase III trial for myelofibrosis (Combination therapy) in April 2026 (PO, Tablet) (NCT07357727)
  • 14 Jan 2026 Novartis Pharmaceuticals plans a phase Ib drug drug interaction trial for Cancer (Late-stage disease) in May 2026 (PO) (NCT07340190)

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