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OPN 7486

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Drug Profile

OPN 7486

Alternative Names: OPN-7486; PLX 7486; PLX7486-TsOH

Latest Information Update: 02 Feb 2024

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At a glance

  • Originator Plexxikon
  • Developer NHS Greater Glasgow and Clyde; Opna Bio; Plexxikon
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; TrkA receptor antagonists; TrkB receptor antagonists; TrkC receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Cancer
  • Discontinued Pancreatic cancer; Solid tumours

Most Recent Events

  • 25 Jul 2023 Opna Bio plans a phase II trial for Cancer in the first half of 2024 (Opna Bio pipeline, July 2023)
  • 21 Nov 2022 Opna Bio acquires PLX 2853 from Plexxikon
  • 21 Nov 2022 Phase-I clinical trials in Cancer in Switzerland (PO) (Opna Bio pipeline; November 2022)

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