HL 2351
Alternative Names: GX P4; GX-P4 - Genexine; HL2351; Recombinant human interleukin-1 receptor antagonist hybrid Fc; rhIL-1Ra-hyFcLatest Information Update: 31 Aug 2017
At a glance
- Originator Genexine
- Developer Handok Inc
- Class Anti-inflammatories; Antirheumatics; Biobetters; Biological proteins; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins
- Mechanism of Action Interleukin 1 receptor antagonists; Interleukin 6 inhibitors; Interleukin-8 expression inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Discontinued Cryopyrin-associated periodic syndromes; Rheumatoid arthritis
Most Recent Events
- 31 Aug 2017 Discontinued - Phase-I for Rheumatoid arthritis in South Korea (SC)
- 31 Aug 2017 Discontinued - Phase-II for Cryopyrin associated Periodic Syndromes (In children, In the elderly, In adults) in South Korea (unspecified route)
- 03 Jan 2017 Handok Pharmaceuticals terminates a phase II trial in Cryopyrin associated Periodic Syndromes (In children, In adults, In the elderly) in South Korea due to difficulty in recruiting patients (NCT02853084)