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HL 2351

Drug Profile

HL 2351

Alternative Names: GX P4; GX-P4 - Genexine; HL2351; Recombinant human interleukin-1 receptor antagonist hybrid Fc; rhIL-1Ra-hyFc

Latest Information Update: 31 Aug 2017

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At a glance

  • Originator Genexine
  • Developer Handok Inc
  • Class Anti-inflammatories; Antirheumatics; Biobetters; Biological proteins; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins
  • Mechanism of Action Interleukin 1 receptor antagonists; Interleukin 6 inhibitors; Interleukin-8 expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cryopyrin-associated periodic syndromes; Rheumatoid arthritis

Most Recent Events

  • 31 Aug 2017 Discontinued - Phase-I for Rheumatoid arthritis in South Korea (SC)
  • 31 Aug 2017 Discontinued - Phase-II for Cryopyrin associated Periodic Syndromes (In children, In the elderly, In adults) in South Korea (unspecified route)
  • 03 Jan 2017 Handok Pharmaceuticals terminates a phase II trial in Cryopyrin associated Periodic Syndromes (In children, In adults, In the elderly) in South Korea due to difficulty in recruiting patients (NCT02853084)
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