Drug Profile


Alternative Names: E-58425; MR308; Tramadol/Celecoxib

Latest Information Update: 06 Jun 2018

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At a glance

  • Originator ESTEVE
  • Developer ESTEVE; Mundipharma GmbH
  • Class Analgesics; Anti-inflammatories; Cyclohexanols; Dimethylamines; Non-opioid analgesics; Nonsteroidal anti-inflammatories; Opioid analgesics; Phenyl ethers; Pyrazoles; Small molecules; Sulfonamides
  • Mechanism of Action Adrenergic uptake inhibitors; Cyclo-oxygenase 2 inhibitors; Opioid mu receptor agonists; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute pain
  • Phase II Dental pain; Pain

Most Recent Events

  • 04 Jan 2018 Mundipharma completes the STARDOM1 trial for Acute pain in Canada, Germany, Hungary, Italy, Poland and Spain (PO) (NCT02982161)
  • 11 May 2017 Chemical structure information added
  • 05 Apr 2017 Phase-III clinical trials in Acute pain in Poland (PO) (NCT03062644)
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