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Relatlimab - Bristol-Myers Squibb/Ono Pharmaceuticals

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Drug Profile

Relatlimab - Bristol-Myers Squibb/Ono Pharmaceuticals

Alternative Names: Anti-LAG-3; Anti-LAG-3 monoclonal antibody - Bristol-Myers Squibb; Anti-LAG-3-Bristol-Myers-Squibb; Anti-lymphocyte activation gene 3 monoclonal antibody; BMS 986016; ONO-4482

Latest Information Update: 06 Dec 2024

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Herlev Hospital; Multiple Myeloma Research Consortium; National Institute of Neurological Disorders and Stroke; Ono Pharmaceutical; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UCLAs Jonsson Comprehensive Cancer Center; University Hospital of Essen; University of Miami; University of Pittsburgh
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Chordoma; Colorectal cancer; Gastric cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Soft tissue sarcoma; Solid tumours; Uveal melanoma
  • Phase I/II Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Fallopian tube cancer; Hodgkin's disease; Mantle-cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer
  • No development reported Glioblastoma

Most Recent Events

  • 07 Sep 2024 Efficacy data from a phase II trial in Non-small cell lung cancer presented at the 25th World Conference on Lung Cancer (WCLC-2024)
  • 24 Jul 2024 Bristol-Myers Squibb terminated a phase-I trial in Malignant melanoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Canada, Germany, Spain, Belgium (IV) due to change in business objectives (NCT03978611) (EudraCT2019-000132-25)
  • 28 Jun 2024 No recent reports of development identified for phase-I development in Glioblastoma(Combination therapy, Recurrent, Second-line therapy or greater) in USA (IV, Infusion)

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