Relatlimab - Bristol-Myers Squibb/Ono Pharmaceuticals

Drug Profile

Relatlimab - Bristol-Myers Squibb/Ono Pharmaceuticals

Alternative Names: Anti-LAG-3; Anti-LAG-3 monoclonal antibody; Anti-LAG-3 monoclonal antibody - Bristol-Myers Squibb; Anti-LAG-3-Bristol-Myers-Squibb; Anti-lymphocyte activation gene 3 monoclonal antibody; BMS 986016; ONO-4482

Latest Information Update: 07 Aug 2018

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Ono Pharmaceutical; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD223 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Malignant melanoma
  • Phase II Colorectal cancer; Gastric cancer; Renal cell carcinoma
  • Phase I/II Solid tumours
  • Phase I Glioblastoma
  • No development reported Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Hodgkin's disease; Mantle-cell lymphoma; Non-Hodgkin's lymphoma

Most Recent Events

  • 01 Aug 2018 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins plans the REACTION phase I/II trial for Oesophageal and Gastric cancer (Combination therapy) in USA , (NCT03610711)
  • 31 Jul 2018 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Bristol-Myers Squibb plan a phase II trial for Solid tumours (Combination therapy, Second-line therapy or greater) in USA (NCT03607890)
  • 25 May 2018 Bristol-Myers Squibb initiates a phase I/II trial for Solid tumours (Late-stage disease, Combination therapy, Metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT03459222)
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