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Cabiralizumab - Bristol-Myers Squibb/Five Prime Therapeutics

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Drug Profile

Cabiralizumab - Bristol-Myers Squibb/Five Prime Therapeutics

Alternative Names: BMS-986227; Cabiralizumab; FPA-008; ONO-4687

Latest Information Update: 23 Oct 2024

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At a glance

  • Originator Five Prime Therapeutics
  • Developer Bristol-Myers Squibb; Five Prime Therapeutics; NYU Langone Health; Pyxis Oncology; University of Chicago; University of Michigan Rogel Cancer Center; Yale University
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Macrophage colony-stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pigmented villonodular synovitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Liver cancer
  • Discontinued Cancer; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Peripheral T-cell lymphoma; Pigmented villonodular synovitis; Renal cell carcinoma; Rheumatoid arthritis; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 23 Oct 2024 Discontinued - Phase-I for Cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan (IV)
  • 23 Oct 2024 Discontinued - Phase-I for Cancer (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in Japan (IV)
  • 23 Oct 2024 Discontinued - Phase-I for Malignant melanoma (Combination therapy, Inoperable/Unresectable, Late-stage disease, Second-line therapy or greater) in USA (IV)

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